ARN-509 , ≥98% , 956104-40-8

CAS NO.：956104-40-8

Empirical Formula: C21H15F4N5O2S

Molecular Weight: 477.43

MDL number: MFCD22380626

EINECS: 807-449-9

PRODUCT Properties

• Density: 1.59±0.1 g/cm3(Predicted)
• storage temp.: Store at -20°C
• solubility: ≥23.85 mg/mL in DMSO; insoluble in H2O; ≥7.33 mg/mL in EtOH
• form: solid
• pka: 13.83±0.46(Predicted)
• color: White to off-white
• InChI: InChI=1S/C21H15F4N5O2S/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31)
• InChIKey: HJBWBFZLDZWPHF-UHFFFAOYSA-N
• SMILES: C(NC)(=O)C1=CC=C(N2C(=S)N(C3=CC(C(F)(F)F)=C(C#N)N=C3)C(=O)C32CCC3)C=C1F

Description and Uses

Apalutamide is a second-generation antiandrogen used in the treatment of prostate cancer. It is a potent antagonist of androgen receptor with IC50 value of 16 nM. Binds androgen receptors, thereby inhibiting nuclear translocation, DNA binding and transcriptional activation. ARN-509 has therapeutic applications in non-metastatic, castration-resistant prostate cancer.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P280-P305+P351+P338