A0778112
Ascomycin , ≥97.0% , 104987-12-4
Synonym(s):
Changchuanmycin;FK-520;FR900520;Immunomycin;L 683590
CAS NO.：104987-12-4
Empirical Formula: C43 H69 N O12
Molecular Weight: 792.01
MDL number: MFCD06198665
EINECS: 600-627-5
| Pack Size | Price | Stock | Quantity |
| 25MG | RMB279.20 | In Stock |
|
| 100MG | RMB719.20 | In Stock |
|
| 500MG | RMB2399.20 | In Stock |
|
| 1g | RMB3999.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 153-157°C |
| Boiling point: | 868℃ |
| Density | 1.19±0.1 g/cm3(Predicted) |
| Flash point: | >110°(230°F) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | ≥38.9 mg/mL in DMSO; insoluble in H2O; ≥98.6 mg/mL in EtOH |
| form | Powder |
| pka | 9.97±0.70(Predicted) |
| color | White to off-white |
| Water Solubility | Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water |
| InChIKey | ZDQSOHOQTUFQEM-AMASXYNMSA-N |
Description and Uses
Everolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a silyl-protected hydroxyethyl triflate moiety, followed by addition of an ethylhydroxy moiety to provide greater stability and bioavailability. Like all tacrolimus analogues, everolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Everolimus is extensively cited in the literature with over 2,000 citations.
Safety
| Symbol(GHS) |   GHS02,GHS07 |
| Signal word | Danger |
| Hazard statements | H225-H302+H332-H319-H302-H312-H332 |
| Precautionary statements | P210-P305+P351+P338-P261-P280h-P301+P312a-P304+P340-P321-P501a |
| Hazard Codes | Xn,F |
| Risk Statements | 20/21/22-36-11 |
| Safety Statements | 36/37-16 |
| RIDADR | UN 1648 3 / PGII |
| WGK Germany | 3 |
| RTECS | KD4185000 |
| F | 10 |
| HS Code | 29419090 |
