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A0768212

Agomelatine , ≥98%(HPLC) , 138112-76-2

Synonym(s):
N-[2-(7-Methoxy-1-naphthalenyl)ethyl]-acetamide;S-20098

CAS NO.:138112-76-2

Empirical Formula: C15H17NO2

Molecular Weight: 243.3

MDL number: MFCD00916659

EINECS: 629-727-7

Pack Size Price Stock Quantity
5MG RMB23.20 In Stock
25MG RMB32.00 In Stock
250mg RMB52.00 In Stock
1G RMB74.40 In Stock
50mg RMB79.20 In Stock
5G RMB282.40 In Stock
25G RMB1055.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 107-109°C
Boiling point: 478.8±28.0 °C(Predicted)
Density  1.109±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: >50mg/mL
pka 16.17±0.46(Predicted)
form  powder
color  white to off-white
Merck  14,190
InChI InChI=1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/h3-7,10H,8-9H2,1-2H3,(H,16,17)
InChIKey YJYPHIXNFHFHND-UHFFFAOYSA-N
SMILES C(NCCC1=C2C(C=CC(OC)=C2)=CC=C1)(=O)C
CAS DataBase Reference 138112-76-2(CAS DataBase Reference)

Description and Uses

Agomelatine is an agonist of melatonin (MT) receptors and a derivative of melatonin . It binds to MT1 and MT2 receptors (Kis = 0.14 and 0.41 nM, respectively) and has an EC50 value of 0.1 nM in a [35S]GTPγS binding assay using CHO cells expressing MT2 receptors. Agomelatine is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B and 5-HT2C (Kis = 0.26 and 0.71 nM, respectively, for the human receptors). Agomelatine (40 mg/kg) inhibits the penile erection response induced by the 5-HT2 agonist Ro 60-0175 in rats. It also increases extracellular levels of noradrenaline and dopamine in the frontal cortex of freely moving rats when administered at doses ranging from 20 to 80 mg/kg. Agomelatine (10 mg/kg) reduces immobility time in the forced swim test and increases the amount of time spent in the open arms of the elevated plus maze in mice, indicating antidepressant-like and anxiolytic-like activity, in a transgenic neuroendocrine model of depression. It also increases the rate of readjustment to circadian activity cycles following an induced phase shift.

Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively.

Safety

Symbol(GHS) 
GHS09
Signal word  Warning
Hazard statements  H400
Precautionary statements  P273
Hazard Codes  N
Risk Statements  50
Safety Statements  61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS  AC5956323
HS Code  29241990
Toxicity mouse,LD50,oral,> 1gm/kg (1000mg/kg),United States Patent Document. Vol. #5318994,

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