Amlodipine , 98% , 88150-42-9
CAS NO.：88150-42-9
Empirical Formula: C20H25ClN2O5
Molecular Weight: 408.88
MDL number: MFCD00864687
EINECS: 1308068-626-2
| Pack Size | Price | Stock | Quantity |
| 1G | RMB24.00 | In Stock |
|
| 5G | RMB28.00 | In Stock |
|
| 25G | RMB108.80 | In Stock |
|
| 100G | RMB385.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 178-179°C |
| Boiling point: | 527.2±50.0 °C(Predicted) |
| Density | 1.227±0.06 g/cm3(Predicted) |
| RTECS | US7968329 |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). |
| pka | pKa 8.6 (Uncertain) |
| form | Almost white crystal powder |
| color | White |
| Water Solubility | 75.3 mg/L |
| BCS Class | 1 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 88150-42-9(CAS DataBase Reference) |
| EPA Substance Registry System | 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester (88150-42-9) |
Description and Uses
Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle. Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues. Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition in vitro and in vivo. Formulations containing amlodipine have been used in the treatment of hypertension.
A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer.
Safety
| Symbol(GHS) |     GHS05,GHS06,GHS08,GHS09 |
| Signal word | Warning |
| Hazard statements | H301-H318-H373-H400-H410 |
| Precautionary statements | P260-P280i-P301+P310a-P305+P351+P338-P405-P501a |
| HazardClass | IRRITANT |
| HazardClass | 6.1 |
| Hazardous Substances Data | 88150-42-9(Hazardous Substances Data) |
| Toxicity | TDLo orl-chd: 400 mg/kg:BPR AJEMEN 18,581,2000 |
