Pseudouridine , ≥98% , 1445-07-4

CAS NO.：1445-07-4

Empirical Formula: C9H12N2O6

Molecular Weight: 244.2

MDL number: MFCD00038458

PRODUCT Properties

• Melting point: 222 °C
• Density: 1.641±0.06 g/cm3(Predicted)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: Methanol (Very Slightly, Heated), Water (Slightly, Sonicated, Heated)
• pka: 8.52±0.10(Predicted)
• form: Solid
• color: White to Off-White
• PH: ～9.0
• λmax: 264nm(MeOH)(lit.)
• InChI: InChI=1/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/s3
• InChIKey: PTJWIQPHWPFNBW-IZFRNLNUNA-N
• SMILES: O[C@@H]1[C@@H]([C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O)O |&1:1,2,3,7,r|

Description and Uses

β-Pseudouridine is the C-5 glycoside isomer of the nucleoside uridine. It is formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme. Pseudouridine is found in tRNAs from bacteria, archaea, and eukaryotes. In vitro, it reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner.

An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• HS Code: 2934.99.9001