Home Categories Biochemical Engineering Hypoxanthine
A4711212

Hypoxanthine , 99% , 68-94-0

Synonym(s):
6-Hydroxypurine;Hypoxanthine;Hypoxanthine - CAS 68-94-0 - Calbiochem

CAS NO.:68-94-0

Empirical Formula: C5H4N4O

Molecular Weight: 136.11

MDL number: MFCD00005725

EINECS: 200-697-3

Pack Size Price Stock Quantity
5G RMB24.00 In Stock
25G RMB39.20 In Stock
100G RMB90.40 In Stock
500g RMB352.80 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: >300 °C (lit.)
Boiling point: 250.36°C (rough estimate)
Density  1.4295 (rough estimate)
refractive index  1.8500 (estimate)
storage temp.  2-8°C
solubility  1 M NaOH: 25 mg/mL
form  powder
pka 8.7(at 25℃)
color  Colorless to yellow to brown, darken on storage with no loss of purity
Odor Odorless
Water Solubility  practically insoluble
Merck  14,4869
BRN  5811
InChIKey FDGQSTZJBFJUBT-UHFFFAOYSA-N
LogP -0.910 (est)

Description and Uses

Hypoxanthine is a naturally occurring purine derivative and intermediate in the synthesis of uric acid. It is elevated in the spinal fluid of patients with Lesch-Nyhan syndrome, a metabolic disorder whose symptoms include cerebral palsy, cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia. Injection of hypoxanthine (10 μM) increases succinate dehydrogenase and complex II activities and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rat striatum. It is also used to induce hyperuricemia in mice for use in the development of hypouricemic agents.

Hypoxanthine, is used as a marker for energy perturbation in hypoxia/ ischemia. The compound has been used in studies as in indicator, along with uric acid and allantoin , of in vivo free radical reactions. It has been also used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol ? (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus. It is also used as a pharmaceutical intermediate.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264b-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362+P364-P403+P233-P501c
Hazard Codes  Xn
Risk Statements  36/37/38-22-40
Safety Statements  22-24/25-37/39-26-36
WGK Germany  3
RTECS  UP0791000
Hazard Note  Harmful
TSCA  Yes
HS Code  29335990
Toxicity LD50 intraperitoneal in mouse: 750mg/kg

RELATED PRODUCTS