Home Categories Biochemical Engineering Angiotensin Ⅱ, human
A0654612

Angiotensin Ⅱ, human , 90% , 4474-91-3

Synonym(s):
Ang II;Angiotensin 2;Angiotensin II;Angiotensin II, Human - CAS 4474-91-3 - Calbiochem;DRVYIHPF

CAS NO.:4474-91-3

Empirical Formula: C50H71N13O12

Molecular Weight: 1046.2

MDL number: MFCD00161484

EINECS: 2017-001-1

Pack Size Price Stock Quantity
5MG RMB239.20 In Stock
10MG RMB399.20 In Stock
25MG RMB559.20 In Stock
100mg RMB1599.20 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Boiling point: 809.08°C (rough estimate)
Density  1.1257 (rough estimate)
refractive index  1.6700 (estimate)
RTECS  BW2165000
storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility  insoluble in DMSO; insoluble in EtOH; ≥100.2 mg/mL in H2O
form  Powder
pka pK1: 10.37 (25°C)
color  orange
Water Solubility  Soluble in Water (25 mg/ml), and 5% Acetic Acid (1 mg/ml).
Sequence H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
Stability: Hygroscopic
InChIKey CZGUSIXMZVURDU-JZXHSEFVSA-N

Description and Uses

It is known that tumor tissues including metastatic lymph nodes are composed of newly growing vessels which lack blood flow autoregulation and are influenced only secondarily by the responding somatic vessels. Human angiotensin II (AT II). a vasopressor, was introduced in Japan to improve the efficacy of systemic chemotherapy. In patients with various advanced cancers, i.v. infusion of AT II to achieve a mean blood pressure of 1.5 times of baseline (but not over 150 mm Hg) followed by a bolus injection of conventional cytotoxic agents increases blood flow 5-7 fold in tumor tissues and therefore, increases drug delivery to the target tissue resulting in enhanced chemotherapeutic effects. This induced-hypertension chemotherapy regimen can be performed safely with minimal side effects.

Angiotensin II is a peptide hormone known best as a vasoconstrictor with central roles in chronic hypertension, heart failure, and stroke. It is an octapeptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE). Angiotensin II is a ligand for at least two distinct receptors, AT1 and AT2, each evoking distinct signaling pathways and physiological responses. The development of antagonists for specific angiotensin II receptor subtypes represents a valuable alternative to ACE inhibitors.

Safety

WGK Germany  3

RELATED PRODUCTS