Home Categories Biochemical Engineering Amygdalin
A0644512

Amygdalin , 97% , 29883-15-6

Synonym(s):
D-Mandelonitrile 6-O-β-D-glucosido-β-D-glucoside;D-Mandelonitrile-β-gentiobioside;Amygdaloside;Laetrile

CAS NO.:29883-15-6

Empirical Formula: C20H27NO11

Molecular Weight: 457.43

MDL number: MFCD00006598

EINECS: 249-925-3

Pack Size Price Stock Quantity
1G RMB47.20 In Stock
5G RMB115.20 In Stock
25G RMB400.00 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: 223-226 °C
Boiling point: 563.27°C (rough estimate)
alpha  -38.5 º (c=4, H2O)
Density  1.4474 (rough estimate)
refractive index  -40 ° (C=2, H2O)
storage temp.  Sealed in dry,Room Temperature
solubility  H2O: 0.1 g/mL hot, clear to very faintly turbid, colorless
pka 12.69±0.70(Predicted)
form  Powder
color  White to Off-white
optical activity [α]20/D 39±2°, c = 2% in H2O
Water Solubility  83 g/L (25 ºC)
Merck  14,597
BRN  66856
Stability: Hygroscopic
InChIKey XUCIJNAGGSZNQT-SWRVSKMJSA-N
LogP -2.237 (est)
CAS DataBase Reference 29883-15-6(CAS DataBase Reference)

Description and Uses

Amygdalin is a cyanogenic glycoside that has been found in seeds from plants of the Rosaceae family and has diverse biological activities. It induces cell cycle arrest at the G0/G1 phase, decreases cyclin A and Cdk2 levels, and inhibits cell growth in UMUC-3, RT112, and TCCSUP bladder cancer cells when used at concentrations ranging from 1.25 to 10 mg/ml. Amygdalin (3 mg/kg) reduces the number of primary microtubules and microvessels in aortic rings isolated from rats with diabetes induced by streptozotocin . In vivo, amygdalin reduces triglyceride, total cholesterol, and LDL levels and aortic sinus plaque area in an LDLR-/- mouse model of atherosclerosis. It also reduces production of TNF-α, IL-1β, and IL-6, as well as neutrophil and macrophage infiltration, in bronchoalveolar lavage fluid (BALF) in a mouse model of LPS-induced acute lung injury.

Amygdalin, a cyanide containing glycoside, may be used as a substrate to identify, differentiate and characterize enzymes such as maltase(s), emulsin(s) and β-glucosidase(s).

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  22
Safety Statements  26-36/37/39-45-24/25
RIDADR  2811
WGK Germany  3
RTECS  OO8450000
10-21
HazardClass  6.1(b)
PackingGroup  III
HS Code  29389090
Hazardous Substances Data 29883-15-6(Hazardous Substances Data)
Toxicity LD50 orl-rat: 522 mg/kg WJMDA2 134,97,81

RELATED PRODUCTS