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A0616812

Anisomycin from Streptomyces griseolus , 97% , 22862-76-6

Synonym(s):
(2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate;2-( p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate;2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate;2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate;Flagecidin

CAS NO.:22862-76-6

Empirical Formula: C14H19NO4

Molecular Weight: 265.3

MDL number: MFCD00077650

EINECS: 245-269-7

Pack Size Price Stock Quantity
5MG RMB134.40 In Stock
25MG RMB340.00 In Stock
100MG RMB956.80 In Stock
500mg RMB3503.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 140-141 C
Boiling point: 408.52°C (rough estimate)
alpha  D23 -30° (methanol)
Density  1.1356 (rough estimate)
refractive index  1.5230 (estimate)
Flash point: 87℃
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  methanol: 20 mg/mL, clear, colorless to faintly yellow
form  solid
pka 7.9(at 25℃)
color  white
Water Solubility  Soluble in water at 2 mg/ml, in DMSO at 20mg/ml, and in methanol at 20mg/ml
λmax 283nm(EtOH)(lit.)
Merck  14,670
BRN  20705
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey YKJYKKNCCRKFSL-RDBSUJKOSA-N

Description and Uses

Anisomycin (22862-76-6) activates JNK/SAPKs and reduces c-fos and c-jun. Protein synthesis inhibitor. Anisomycin induces apoptosis and sensitizes cells to anoikis. Cell permeable.

It is applied as an antiparasitic agent and antineoplastic agent. It acts as a protein synthesis inhibitor (blocks translation), potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. It also scts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD). Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK).

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P405-P501
Hazard Codes  T,Xn
Risk Statements  25-36/37/38-20/21/22
Safety Statements  45-36-26
RIDADR  UN 3462 6.1/PG 3
WGK Germany  3
RTECS  BZ9800000
3-10
HazardClass  6.1(b)
PackingGroup  III
HS Code  29419090
Toxicity LD50 orl-rat: 72 mg/kg ANTCAO 5,490,55

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