SilybinmixtureofSilybinAandB

Synonym(s):
(2R,3R)-3,5,7-Trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin-6-yl]chroman-4-one;2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-(3,5,7-trihydroxy-4-oxobenzopyran-2-yl)benzodioxin;flavolignans;Silibinin;Silybin

CAS NO.：

Empirical Formula: C25H22O10

Molecular Weight: 482.44

MDL number: MFCD00872186

EINECS: 245-302-5

PRODUCT Properties

• Melting point: 164-174°C
• Boiling point: 793.0±60.0 °C(Predicted)
• alpha: D20 +11° (c = 0.25 in acetone + alcohol)
• Density: 1.527±0.06 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: Acetone (Sparingly), DMSO, Methano (Sparingly)
• form: Solid
• pka: pKa 6.42±0.04 (Uncertain)
• color: Pale Yellow
• Water Solubility: 54mg/L(24.99 ºC)
• Merck: 13,8607
• Stability: Stable. Incompatible with strong oxidizing agents, strong bases.
• LogP: 4.232 (est)
• CAS DataBase Reference: 22888-70-6(CAS DataBase Reference)

Description and Uses

Silybin, also known as silibinin, is the principal biologically active constituent of the silymarin complex (about 70–80%) and is a mixture of silybin A and silybin B. Pharmacological research demonstrated that silybin has shown pleiotropic biological properties, including potent antioxidant, anti-inflammatory, anticancer, antidiabetic, hepatoprotective, neuroprotective, antiviral, antimicrobial and immunosuppressive activities. Silibinin demonstrates promising anticancer effects in vitro and in vivo[1].

Labelled Silybin (S465850). Hepatoprotectant.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-37/39-24/25-22-36
• RIDADR: 3172
• WGK Germany: 3
• RTECS: DJ2981770
• HS Code: 29329990
• Toxicity: LD50 intravenous in mouse: 1056mg/kg