Acitretin , 98% , 55079-83-9

Synonym(s):
9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid;Acitretin

CAS NO.：55079-83-9

Empirical Formula: C21H26O3

Molecular Weight: 326.43

MDL number: MFCD00866632

EINECS: 259-474-4

PRODUCT Properties

• Melting point: 228-230°C
• Boiling point: 404.46°C (rough estimate)
• Density: 1.1348 (rough estimate)
• refractive index: 1.4700 (estimate)
• storage temp.: -20°C
• solubility: Practically insoluble in water, sparingly soluble in tetrahydrofuran, slightly soluble in acetone and in ethanol (96 per cent), very slightly soluble in cyclohexane.
• form: powder
• pka: 4.72±0.33(Predicted)
• color: Light yellow to yellow
• λmax: 352nm(MeOH)(lit.)
• Merck: 14,112
• Stability: LIGHT SENSITIVE

Description and Uses

Acitretin is the free acid form of etretinate useful in the treatment of severe psoriasis and other disorders of keratinization. Although the two compounds have virtually the same efficacy and teratogenic side-effects, acitretin is advantageous for child-bearing women, as its shorter half-life reduces the necessary contraception period from two years to only one month after treatment ceases.

antipsoriatic;binds to nuclear receptors that regulate gene transcription

Safety

• Symbol(GHS): GHS07,GHS08,GHS09
• Signal word: Danger
• Hazard statements: H315-H319-H360-H410
• Precautionary statements: P201-P273-P302+P352-P305+P351+P338-P308+P313
• Hazard Codes: T,N
• Risk Statements: 61-36/38-50/53
• Safety Statements: 53-26-45-60-61-37/39
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• RTECS: RA8460000
• F: 8-10-21
• HazardClass: 9
• PackingGroup: III
• HS Code: 2918992090
• Toxicity: LD50 i.p. in mice (mg/kg): >4000 (1 day), 700 (10 days), 700 (20 days) (Bollag, 1978)