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A0614750

Letrozole , 98% , 112809-51-5

Synonym(s):
4,4ʹ-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile, 1-( bis-(4-Cyanophenyl)methyl)-1,2,4-triazole;4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile;Aromatase Inhibitor II, Letrozole - CAS 112809-51-5 - Calbiochem;Letrozole

CAS NO.:112809-51-5

Empirical Formula: C17H11N5

Molecular Weight: 285.3

MDL number: MFCD00866241

EINECS: 675-034-8

Pack Size Price Stock Quantity
1g RMB72.80 In Stock
5g RMB226.40 In Stock
25g RMB728.80 In Stock
100g RMB2092.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 181-183°C
Boiling point: 563.5±60.0 °C(Predicted)
Density  1.21±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: >50mg/mL
pka 1.52±0.11(Predicted)
form  White powder
color  white to off-white
Merck  14,5450
InChI InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
InChIKey HPJKCIUCZWXJDR-UHFFFAOYSA-N
SMILES C(C1=CC=C(C=C1)C#N)(C1=CC=C(C=C1)C#N)N1C=NC=N1
CAS DataBase Reference 112809-51-5(CAS DataBase Reference)

Description and Uses

Letrozole, also known as Femara, is an orally active aromatase inhibitor that works by competitively inhibiting aromatase. This inhibition prevents the conversion of androgens to estrogen (estrogen stimulates breast tissues and breast cancer reoccurrence) and gonadal steroidogenesis. It can be used for the treatment of breast cancer that is hormonally-responsive or has an unknown receptor status in postmenopausal women. Besides this, Letrozole also has some off-label use such as ovarian stimulation, pretreatment of termination of pregnancy, treatment of gynecomastia, treatment of endometriosis, and promoting spermatogenesis for male patients of nonobstructive azoospermia.

A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic

Safety

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H361fd-H373
Precautionary statements  P202-P260-P280-P308+P313-P405-P501
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  DI4957000
HS Code  2933997500
Hazardous Substances Data 112809-51-5(Hazardous Substances Data)

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