Home Categories Biochemical Engineering 1-Aminocyclopropanecarboxylic acid
A0609212

1-Aminocyclopropanecarboxylic acid , 98% , 22059-21-8

Synonym(s):
1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem;ACPC

CAS NO.:22059-21-8

Empirical Formula: C4H7NO2

Molecular Weight: 101.1

MDL number: MFCD00009944

EINECS: 606-917-8

Pack Size Price Stock Quantity
50MG RMB30.40 In Stock
250MG RMB42.40 In Stock
1G RMB46.40 In Stock
5G RMB139.20 In Stock
25G RMB403.20 In Stock
100G RMB1551.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 229-231 °C (lit.)
Boiling point: 189.47°C (rough estimate)
Density  1.2245 (rough estimate)
refractive index  1.4340 (estimate)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  DMSO (Slightly), Water (Slightly)
pka 2.29±0.20(Predicted)
form  Powder and Granules
color  White to off-white
Water Solubility  Soluble in water.
BRN  2076413
Stability: Store in freezer at -20°C
InChI InChI=1S/C4H7NO2/c5-4(1-2-4)3(6)7/h1-2,5H2,(H,6,7)
InChIKey PAJPWUMXBYXFCZ-UHFFFAOYSA-N
SMILES C1(N)(C(O)=O)CC1
CAS DataBase Reference 22059-21-8(CAS DataBase Reference)

Description and Uses

1-Aminocyclopropanecarboxylic acid (ACPC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. ACPC has been shown to modulate NMDA receptor activity by acting as a partial agonist at the glycine-binding site on NMDA receptors (EC50 = 0.7-0.9 μM) in the presence of low levels (1 μM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 μM) of glutamate. This compound has been reported to protect against neuron cell death in in vivo models of ischemia by enabling moderate levels of NMDA receptor activation and attenuating any excess NMDA receptor signaling that may lead to neurotoxicity.

1-Aminocyclopropane-1-carboxylic Acid is an intermediate in the conversion of methionine to ethylene during the ripening in apples. It also plays an important role in the biosynthesis of the plant hormone ethylene.1-Aminocyclopropane-1-carboxylic Acid is shown to block convulsions and death produced by NMDA exposure, significantly reducing seizure induction and cell death of NMDA-treated hippocampal neurons. 1-Aminocyclopropane-1-carboxylic Acid is produced endogenously in the tomato and other higher plants as a product of the action of 1-aminocyclopropane-1-carboxylic acid synthase in the biosynthesis of ethylene.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  GZ1110000
Hazard Note  Irritant
HS Code  29213000

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