A0605050
MK886 , 98% , 118414-82-7
Synonym(s):
3-[1-( p-Chlorobenzyl)-5-(isopropyl)-3- t-butylthioindol-2-yl]-2,2-dimethylpropanoic Acid, Na, COX-1 Inhibitor III, FLAP Inhibitor I, MK886, mPGES-1 Inhibitor I;MK-886 - CAS 118414-82-7 - Calbiochem
CAS NO.：118414-82-7
Empirical Formula: C27H34ClNO2S
Molecular Weight: 472.08
MDL number: MFCD00876710
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB744.00 | In Stock |
|
| 50mg | RMB3144.00 | In Stock |
|
| 100mg | RMB4399.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 295-297°C |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: 32 mg/mL |
| form | White solid. |
| color | white |
| Stability: | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
Description and Uses
MK-886 (118414-82-7) is an inhibitor of leukotriene biosynthesis(IC50 = 2.5 nM in human PMN)1 via 5-lipoxygenase-activating protein (FLAP) inhibition (IC50 = 30 nM)2. MK-886 also inhibits PPARα (80% inhibition at 10 μM).3
Binds to 5-lipoxygenase-activating protein with high affinity and prevents the activation of 5-lipoxygenase, thus inhibiting the biosynthesis of leukotrienes.
Safety
| WGK Germany | 3 |
