4-AminobutyricAcid , Cosmetics , 56-12-2

Synonym(s):
GABA;4-Aminobutanoic acid;gamma-Aminobutyric acid;γ-Aminobutyric acid;Piperidinic acid

CAS NO.：56-12-2

Empirical Formula: C4H9NO2

Molecular Weight: 103.12

MDL number: MFCD00008226

EINECS: 200-258-6

PRODUCT Properties

• Melting point: 195 °C (dec.) (lit.)
• Boiling point: 248.0±23.0 °C(Predicted)
• Density: 1.2300 (estimate)
• refractive index: 1.4650 (estimate)
• FEMA: 4288 | 4-AMINOBUTYRIC ACID
• storage temp.: 2-8°C
• solubility: H₂O: 1 M at 20 °C, clear, colorless
• form: Powder
• pka: 4.031(at 25℃)
• color: White to almost white
• Odor: at 1.00 % in propylene glycol. savory meaty
• Odor Type: meaty
• Water Solubility: SOLUBLE
• Merck: 14,430
• JECFA Number: 1771
• BRN: 906818
• InChIKey: BTCSSZJGUNDROE-UHFFFAOYSA-N
• LogP: -3.17

Description and Uses

4-Aminobutyric acid (GABA) is the chief inhibitory neurotransmitter in the mammalian central nervous system. It plays a role in regulating neuronal excitability throughout the nervous system. In humans, GABA is also directly responsible for the regulation of muscle tone. Although chemically it is an amino acid, GABA is rarely referred to as such in the scientific or medical communities, because the term "amino acid," used without a qualifier, conventionally refers to the alpha amino acids, which GABA is not, nor is it ever incorporated into a protein. In spastic diplegia in humans, GABA absorption becomes impaired by nerves damaged from the condition's upper motor neuron lesion, which leads to hypertonia of the muscles signaled by those nerves that can no longer absorb GABA.

4-Aminobutyric acid is an important inhibitory neurotransmitter in the central nervous system, which has good water solubility and thermal stability. It has been confirmed that GABA, as a small molecular weight non protein amino acid, has edible safety and can be used in the production of beverages and other foods. Studies have shown that a certain amount of GABA can improve the body's sleep quality and reduce blood pressure.The foods contain γ-aminobutyric acid (GABA) at an amount that shows immediate effect of suppressing autonomic nerve activity related to blood pressure increase. Reacts with isothiocyanates to produce thioureas which have antifungal activity.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H312-H315-H319-H332
• Precautionary statements: P280-P305+P351+P338
• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-20/21/22
• Safety Statements: 26-36
• WGK Germany: 2
• RTECS: ES6300000
• Hazard Note: Irritant
• TSCA: Yes
• HS Code: 29224995