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A0511756

PyriproxyfenSolutioninMethanol , 100 μg/mlinmethanol, uncertainty: 3% , 95737-68-1

Synonym(s):
2-[1-Methyl-2-(4-phenoxyphenoxy)ethoxy]pyridine

CAS NO.:95737-68-1

Empirical Formula: C20H19NO3

Molecular Weight: 321.37

MDL number: MFCD01691614

EINECS: 429-800-1

Pack Size Price Stock Quantity
1.2ml RMB63.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 45-47°C
Boiling point: 230-250 °C(Press: 0.2 Torr)
Density  1.32
vapor pressure  2.9 x l0-4 Pa (20 °C)
refractive index  nD20.5 1.5823
storage temp.  0-6°C
solubility  DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 25 mg/ml; Ethanol: 15 mg/ml
form  Solid
pka 3.2 (base, est.)
Water Solubility  0.4 mg l-1 (25 °C)
color  White to off-white
InChI InChI=1S/C20H19NO3/c1-16(23-20-9-5-6-14-21-20)15-22-17-10-12-19(13-11-17)24-18-7-3-2-4-8-18/h2-14,16H,15H2,1H3
InChIKey NHDHVHZZCFYRSB-UHFFFAOYSA-N
SMILES C1(OC(C)COC2=CC=C(OC3=CC=CC=C3)C=C2)=NC=CC=C1
LogP 4.840 (est)
CAS DataBase Reference 95737-68-1(CAS DataBase Reference)
NIST Chemistry Reference Pyriproxyfen(95737-68-1)
EPA Substance Registry System Pyriproxyfen (95737-68-1)

Description and Uses

Pyriproxyfen is a pyridine insecticide that mimics juvenile growth hormone, which prevents larvae from developing into reproduction-capable adults. The LD50 of pyriproxyfen in rats is >5,000 mg/kg, >1,300 mg/cubic meter/4 hours, and >2,000 mg/kg through oral, inhalation, or percutaneous dosing, respectively. It is used as a larvicide in the drinking water of 11 municipalities in Brazil and rumors suggested it may be correlated with the increase in cases of microcephaly in Brazil. The acceptable daily intake determined by the World Health Organization is 0.3 mg/L. The prevalence of microcephaly in Brazil is not higher in municipalities that use pyriproxyfen in the water supply, compared with municipalities that use the larvicide Bti. In addition, in zebrafish, even very high doses (0.1 μg/ml, compared with 0.01 μg/ml used in practice for pest control) pyriproxyfen does not induce microcephaly or other brain malformations. Formulations containing pyriproxyfen are used for flea control in dogs and as an insecticide for ants.

Insecticide.

Safety

Symbol(GHS) 
GHS09
Signal word  Warning
Hazard statements  H410
Precautionary statements  P273-P391-P501
Hazard Codes  N
Risk Statements  50/53
Safety Statements  60-61
RIDADR  UN3077 9/PG 3
WGK Germany  2
RTECS  UT5804000
HazardClass  9
PackingGroup  III
Hazardous Substances Data 95737-68-1(Hazardous Substances Data)
Toxicity LD50 oral in rat: > 5gm/kg

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