Cantharidin , 0.1mg/mlinDMSO , 56-25-7
Synonym(s):
3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione;7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran;Cantharidine;Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione
CAS NO.：56-25-7
Empirical Formula: C10H12O4
Molecular Weight: 196.2
MDL number: MFCD00134968
EINECS: 200-263-3
PRODUCT Properties
| Melting point: | 215-217 °C (lit.) |
| Boiling point: | 253.08°C (rough estimate) |
| Density | 1.0357 (rough estimate) |
| refractive index | 1.4699 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (25 mg/ml warm), acetone (8 mg/ml), ethanol (8 mg/ml warm), chloroform (1:65), ether (1:560), and ethyl acetate (1:150). |
| form | solution |
| color | white |
| Water Solubility | 30mg/L(20 ºC) |
| Merck | 14,1752 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 weeks. |
| InChIKey | DHZBEENLJMYSHQ-XCVPVQRUSA-N |
| LogP | -0.409 (est) |
Description and Uses
Cantharidin (56-25-7) inhibits protein phosphatase 2A (Ki=0.19 μM) and PP1 (Ki=1.1 μM).1 Displays >500-fold selectivity over PP2B. Suppresses growth and migration of PANC-1 pancreatic cancer cells via phosphorylation and degradation of β-catenin.2?Cantharidin arrests G2/M transition via JNK/Sp1-dependent down-regulation of CDK1.3?Cell permeable. Warning: Avoid skin contact, may cause skin irritation or blistering.
Cantharidin is used as a potent inhibitor of PP2A phosphatase activity. It has been shown to stimulate cell cycle progression and induce premature mitosis, used topically (0.7%) as an anti-wart treatment, and has been shown to be active in cervical, tongue, neuroblastoma, bone, leukemia, ovarian, colon, and various other cancer cell lines.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H300-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P301+P310-P302+P352-P305+P351+P338 |
| Hazard Codes | T+,T |
| Risk Statements | 28-36/37/38-38-37-36-23/24/25 |
| Safety Statements | 53-45-36/37/39 |
| RIDADR | UN 2811 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | RN8575000 |
| TSCA | Yes |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| HS Code | 29329990 |
