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A0450056

Cantharidin , 0.1mg/mlinDMSO , 56-25-7

Synonym(s):
3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione;7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran;Cantharidine;Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione

CAS NO.:56-25-7

Empirical Formula: C10H12O4

Molecular Weight: 196.2

MDL number: MFCD00134968

EINECS: 200-263-3

Update time: 2022-07-08

PRODUCT Properties

Melting point: 215-217 °C (lit.)
Boiling point: 253.08°C (rough estimate)
Density  1.0357 (rough estimate)
refractive index  1.4699 (estimate)
storage temp.  2-8°C
solubility  Soluble in DMSO (25 mg/ml warm), acetone (8 mg/ml), ethanol (8 mg/ml warm), chloroform (1:65), ether (1:560), and ethyl acetate (1:150).
form  solution
color  white
Water Solubility  30mg/L(20 ºC)
Merck  14,1752
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 weeks.
InChIKey DHZBEENLJMYSHQ-XCVPVQRUSA-N
LogP -0.409 (est)

Description and Uses

Cantharidin (56-25-7) inhibits protein phosphatase 2A (Ki=0.19 μM) and PP1 (Ki=1.1 μM).1 Displays >500-fold selectivity over PP2B. Suppresses growth and migration of PANC-1 pancreatic cancer cells via phosphorylation and degradation of β-catenin.2?Cantharidin arrests G2/M transition via JNK/Sp1-dependent down-regulation of CDK1.3?Cell permeable. Warning: Avoid skin contact, may cause skin irritation or blistering.

Cantharidin is used as a potent inhibitor of PP2A phosphatase activity. It has been shown to stimulate cell cycle progression and induce premature mitosis, used topically (0.7%) as an anti-wart treatment, and has been shown to be active in cervical, tongue, neuroblastoma, bone, leukemia, ovarian, colon, and various other cancer cell lines.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P310-P302+P352-P305+P351+P338
Hazard Codes  T+,T
Risk Statements  28-36/37/38-38-37-36-23/24/25
Safety Statements  53-45-36/37/39
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS  RN8575000
TSCA  Yes
HazardClass  6.1(a)
PackingGroup  I
HS Code  29329990

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