O-Desmethylvenlafaxine , >98.0%(HPLC) , 93413-62-8

Synonym(s):
4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol;Desvenlafaxine

CAS NO.：93413-62-8

Empirical Formula: C16H25NO2

Molecular Weight: 263.38

MDL number: MFCD00871934

EINECS: 700-516-2

PRODUCT Properties

• Melting point: 208-213°C
• Boiling point: 403.8±25.0 °C(Predicted)
• Density: 1.115±0.06 g/cm3(Predicted)
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: insoluble in EtOH; ≥13.2 mg/mL in DMSO; ≥2.45 mg/mL in EtOH
• form: Solid
• pka: 10.04±0.26(Predicted)
• color: White to off-white
• InChIKey: KYYIDSXMWOZKMP-UHFFFAOYSA-N
• LogP: 0.33 at 25℃ and pH6

Description and Uses

Desvenlafaxine is a new member of the SNRI class of antidepressants. It is marketed as an extended release tablet for once-daily oral treatment of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of the previously marketed antidepressant venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more potent inhibitor of serotonin and norepinephrine reuptake (IC₅₀＝47 and 531 nM, respectively) than that of dopamine (62% inhibition at 100 mM) in in vitro studies. It does not have significant in vitro affinity for other neurotransmitter reporters such as a1-adrenergic, H1-histaminergic, or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a racemic mixture. Specific pharmacological properties of the enantiomers of desvenlafaxine have not been reported.

A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H319
• Precautionary statements: P305+P351+P338
• Hazard Codes: F,T,Xi
• Risk Statements: 11-23/24/25-39/23/24/25-36
• Safety Statements: 7-16-36/37-45-26
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• RTECS: GV8872620
• HS Code: 29225090