Home Categories Biochemical Engineering O-Desmethylvenlafaxine
T3437931

O-Desmethylvenlafaxine , >98.0%(HPLC) , 93413-62-8

Synonym(s):
4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol;Desvenlafaxine

CAS NO.:93413-62-8

Empirical Formula: C16H25NO2

Molecular Weight: 263.38

MDL number: MFCD00871934

EINECS: 700-516-2

Pack Size Price Stock Quantity
1g RMB408.00 In Stock
5g RMB1592.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 208-213°C
Boiling point: 403.8±25.0 °C(Predicted)
Density  1.115±0.06 g/cm3(Predicted)
Flash point: 9℃
storage temp.  2-8°C
solubility  insoluble in EtOH; ≥13.2 mg/mL in DMSO; ≥2.45 mg/mL in EtOH
form  Solid
pka 10.04±0.26(Predicted)
color  White to off-white
InChIKey KYYIDSXMWOZKMP-UHFFFAOYSA-N
LogP 0.33 at 25℃ and pH6

Description and Uses

Desvenlafaxine is a new member of the SNRI class of antidepressants. It is marketed as an extended release tablet for once-daily oral treatment of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of the previously marketed antidepressant venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more potent inhibitor of serotonin and norepinephrine reuptake (IC50=47 and 531 nM, respectively) than that of dopamine (62% inhibition at 100 mM) in in vitro studies. It does not have significant in vitro affinity for other neurotransmitter reporters such as a1-adrenergic, H1-histaminergic, or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a racemic mixture. Specific pharmacological properties of the enantiomers of desvenlafaxine have not been reported.

A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P305+P351+P338
Hazard Codes  F,T,Xi
Risk Statements  11-23/24/25-39/23/24/25-36
Safety Statements  7-16-36/37-45-26
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  GV8872620
HS Code  29225090
Hazardous Substances Data 93413-62-8(Hazardous Substances Data)

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