129298-91-5
Synonym(s):
(Chloracetyl) carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester;, O-(Chloroacetyl-carbamoyl)fumagillol, AGM1470, MetAP-2 Inhibitor II, MetAP2 Inhibitor II, Methionine Aminopeptidase 2 Inhibitor II, TNP470;O-Chloracetyl-carbamoyl fumagillol
CAS NO.：129298-91-5
Empirical Formula: C19H28ClNO6
Molecular Weight: 401.88
MDL number: MFCD00870281
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB2142.29 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 90-93°C |
| alpha | D24 -46.6° (c = 0.44 in CHCl3) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: >15mg/mL |
| pka | 7.19±0.46(Predicted) |
| form | White to light yellow solid |
| color | White to Pale Yellow Waxy |
| Stability: | Hygroscopic |
Description and Uses
TNP-470 is a synthetic analog of fumagillin that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 μM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and microsporidiosis.
TNP-470 is a synthetic analog of fumagillin that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 μM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and microsporidiosis.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 2 |
