≥98%(HPLC) , 935666-88-9

Synonym(s):
(S)-5-Chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine;5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine;AZD-1480

CAS NO.：935666-88-9

Empirical Formula: C14H14ClFN8

Molecular Weight: 348.77

MDL number: MFCD16038904

Pack Size	Price	Stock	Quantity
5mg	RMB1293.00	In Stock
25mg	RMB5219.44	In Stock
others			Enquire

Update time: 2022-07-08

PRODUCT Properties

Melting point:	>205°C (dec.)
Boiling point:	575.2±60.0 °C(Predicted)
Density	1.517
storage temp.	-20°C
solubility	Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly, Heat
form	powder
pka	13.73±0.10(Predicted)
color	white to beige
InChI	InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
InChIKey	PDOQBOJDRPLBQU-QMMMGPOBSA-N
SMILES	C1(N[C@H](C2=NC=C(F)C=N2)C)=NC=C(Cl)C(NC2C=C(C)NN=2)=N1

Description and Uses

AZD1480 has been used as an inhibitor of janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) in an in vitro cell model of upper gastrointestinal adenocarcinoma. It has also been used in combination with bortezomib to study tumor-associated macrophage-mediated survival of myeloma cells.