≥98%(HPLC) , 1254944-66-5
Synonym(s):
1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
CAS NO.：1254944-66-5
Empirical Formula: C18H19NO3S2
Molecular Weight: 361.48
MDL number: MFCD18782736
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB1400.90 | In Stock |
|
| 25mg | RMB5638.04 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 52-55°C |
| Boiling point: | 535.7±50.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥30mg/mL |
| pka | -3.20±0.40(Predicted) |
| form | film |
| color | white to tan |
Description and Uses
REV-ERBα is a nuclear receptor and transcription repressor that coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. SR8278 is an antagonist of REV-ERBα (EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112 . Moreover, SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells. SR8278 has been used, with GSK 4112, to elucidate the role of REV-ERBα in regulating glucagon secretion in pancreatic alpha cells.
SR 8278 is a synthetic antagonist of the nuclear heme receptor REV-ERB.
