S8991614
≥98%(HPLC) , 87860-39-7
Synonym(s):
Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem;FST, Phosphotrienin
| Pack Size | Price | Stock | Quantity |
| 10μG | RMB5242.69 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| storage temp. | -20°C |
| solubility | Soluble in H2O |
| form | Colorless solid |
| Water Solubility | Soluble to 100 mM in water |
| InChIKey | GMNLFZGMQHSFFV-DSXPUHJBNA-N |
| SMILES | [C@@H](OP(O)(O)=O)(C[C@@H](O)/C=C\C=C/C=C/CO)[C@@](O)(C)/C=C/[C@H]1CC=CC(=O)O1.[NaH] |&1:0,7,17,22,r| |
Description and Uses
Fostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation. On a related note, fostriecin was first identified as an antitumor antibiotic.
Antineoplastic. Fostriecin is a Topo II, PP1, and PP2A inhibitor.
