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S8939414

≥98%(HPLC),powder , 18172-33-3

Synonym(s):
CPA;Cyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem

CAS NO.:18172-33-3

Empirical Formula: C20H20N2O3

Molecular Weight: 336.38

MDL number: MFCD00167445

Pack Size Price Stock Quantity
5mg RMB1026.03 In Stock
10mg RMB1784.15 In Stock
50mg RMB6464.07 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 245-246°C
Boiling point: 472.86°C (rough estimate)
Density  1.2171 (rough estimate)
refractive index  1.5700 (estimate)
storage temp.  -20°C
solubility  DMSO: soluble
form  powder
pka 4.50±1.00(Predicted)
color  white to off-white
Water Solubility  Soluble in DMSO (100 mM), ethanol (5 mM), DMF (~20 mg/ml), and 1:1 DMSO:PBS(pH 7.2) (0.5 mg/ml). Insoluble in water.
EPA Substance Registry System Cyclopiazonic acid (18172-33-3)

Description and Uses

Cyclopiazonic acid is a mycotoxin that has been found in Penicillium and Aspergillus and an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA; IC50 = 0.6 μM). In vivo, cyclopiazonic acid (11-14 mg/kg) induces ptosis, hypothermia, tremor, and cachexia, as well as induces lethality (LD50 = 13 mg/kg), in rats. It induces tachycardia and sedation in rabbits when administered at a dose of 10 mg/kg.

Cyclopiazonic acid from?Penicillium cyclopium has been used:

  • as a standard in aflatoxin detection and quantification by thin layer chromatography (TLC)
  • as a component in Ca2+-free DMEM/10% fetal bovine serum (FBS)
  • as a reversible inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) to examine the role of luminal calcium in endoplasmic recticulum (ER)-to-Golgi trafficking
  • as an endoplasmic reticulum Ca2+-ATPase blocker, to treat neurons and also to study the role of the endoplasmic reticulum (ER) in releasing and sustaining Ca2+?during Ca2+-induced Ca2+ release (CICR) to inhibit SERCA

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P264-P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  36/37/39-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  UY8587000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29337900
Hazardous Substances Data 18172-33-3(Hazardous Substances Data)
Toxicity chicken,LD50,oral,12mg/kg (12mg/kg),Poultry Science. Vol. 65(Suppl,

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