Cytidine 5''-triphosphate (CTP) is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases. In the formation of phosphatidylcholine (PC), CTP reacts with phosphocholine, via CTP:phosphocholine cytidylyltransferases, to produce CDP-choline and diphosphate. This is the rate-limiting step in PC synthesis and, as a pivotal step in cell proliferation, can be important in cancer. CTP also interacts with N-acylneuraminate, in a reaction mediated by N-acylneuraminate cytidylyltransferase, to generate an intermediate that is required for sialylation, namely CMP-N-acylneuraminic acid.
Cytidine 5′-triphosphate disodium salt hydrate has been used:
- in the oligonucleotide synthesis for silver nanoclusters?interaction studies
- as an anion source for fluorescence emission and titration curve-analysis of hypocrellin A-zinc(II) complex
- in fluorescence emission experiments of copper(II)–2,6-bis(2-benzimidazolyl)pyridine complex
