≥90%(HPLC),powder , 133407-86-0

Synonym(s):
Carbobenzoxy-L-leucyl-L-leucyl-L-norvalinal, Z-LL-Nva-CHO, Proteasome Inhibitor XII;MG115;MG-115 - CAS 133407-86-0 - Calbiochem;Z-LLnV

CAS NO.：133407-86-0

Empirical Formula: C25H39N3O5

Molecular Weight: 461.59

MDL number: MFCD00671410

PRODUCT Properties

• Boiling point: 678.8±55.0 °C(Predicted)
• Density: 1.082±0.06 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: DMSO: soluble
• form: powder
• pka: 11.14±0.46(Predicted)
• color: white

Description and Uses

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (K_i = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.[Cayman Chemical]

Safety

• WGK Germany: 3