enzymeinhibitor , 100991-92-2

Synonym(s):
2-Hydroxymethyl-3,4-pyrrolidinediol hydrochloride

CAS NO.：100991-92-2

Empirical Formula: C5H12ClNO3

Molecular Weight: 169.61

MDL number: MFCD03427380

PRODUCT Properties

• Melting point: 110-112 °C(Solv: ethyl ether (60-29-7); methanol (67-56-1))
• storage temp.: 2-8°C
• solubility: DMSO: 10 mg/ml; PBS (pH 7.2): 1 mg/ml
• form: A crystalline solid

Description and Uses

1,4-dideoxy-1,4-imino-D-Arabinitol (DAB) is an inhibitor of glycogen phosphorylase, a key enzyme in glycogenolysis. It inhibits glycogenolysis in isolated liver cells (IC₅₀ = 1.0 μM) and in homogenates of cerebral cortex and cerebellum (IC₅₀s = 463 and 383 nM, respectively). DAB is used to inhibit glycogenolysis, in liver and in brain, in various animal models.

1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride has been used as an α-glucosidase (GAA) inhibitor.

Safety

• WGK Germany: 3