Sulfathiazole sodium salt , ≥99% , 144-74-1
Synonym(s):
4-Amino-N-(2-thiazolyl)benzenesulfonamide sodium salt
CAS NO.：144-74-1
Empirical Formula: C9H10N3NaO2S2
Molecular Weight: 279.31
MDL number: MFCD00072133
EINECS: 205-638-5
| Pack Size | Price | Stock | Quantity |
| 100g | RMB363.24 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | Store at -20°C |
| solubility | H2O: soluble50mg/mL |
| form | powder |
| color | white to off-white |
| BRN | 3802297 |
| Stability: | Hygroscopic |
| InChI | InChI=1S/C9H9N3O2S2.Na.H/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9;;/h1-6H,10H2,(H,11,12);; |
| InChIKey | PLYRQFRFHFKJLU-UHFFFAOYSA-N |
| SMILES | S(C1C=CC(N)=CC=1)(=O)(=O)NC1SC=CN=1.[NaH] |
| CAS DataBase Reference | 144-74-1(CAS DataBase Reference) |
| EPA Substance Registry System | Benzenesulfonamide, 4-amino-N-2-thiazolyl-, monosodium salt (144-74-1) |
Description and Uses
Sulfathiazole sodium salt is a short-acting sulfa drug. It was a common oral and topical antibiotic until less toxic alternatives were discovered. It is no longer used in humans. Sulfathiazole is added to the diet of laboratory animals to inhibit folate formation by gut bacteria. This ensures that the animal′s only source of available folate is from their diet. Sulfathiazole is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfathiazole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
Sulfathiazole sodium salt is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA). It can also be used in biological study of thermotherapy and sulfonamide antibiotics deciphered Cyanobacteria and Proteobacteria microbiome in huanglongbing-affected Citrus paradise and Citrus limon.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25-23 |
| WGK Germany | 2 |
| RTECS | WP2450000 |
| F | 10 |
