DiacylglycerolKinaseInhibitorI-CAS93076-89-2-Calbiochem , 93076-89-2

Synonym(s):
6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidin-yl]ethyl]-7-methyl-5H-thiazolo-[3,2-a]-pyrimidin-5-one;6-{2-{4-[(p-Fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one, R59022;Diacylglycerol Kinase Inhibitor I - CAS 93076-89-2 - Calbiochem;R59022;R59022, 6-{2-{4-[(p-Fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one

CAS NO.：93076-89-2

Empirical Formula: C27H26FN3OS

Molecular Weight: 459.58

MDL number: MFCD00055114

PRODUCT Properties

• Boiling point: 619.8±65.0 °C(Predicted)
• Density: 1.26±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: 0.1 M HCl: slightly soluble
• form: solid
• pka: 7.76±0.20(Predicted)
• color: pale yellow
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Description and Uses

R-59022 (93076-89-2) is a diacylglycerol kinase (DAGK) inhibitor, nonselective for DAGK isotypes (IC50=2.8 μM in intact platelets).1 Induces autophagy and apoptosis in NG108-15 neuronal cells via an mTOR-independent mechanism.2 Prevents conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes.3 Blocks filovirus internalization in host cells.4

R-59-022 acts as an inducer of apoptosis in glioblastoma cells and avoids apoptosis in non-cancerous cells. This selectivity makes this drug a highly effective anti-cancer agent. Diacylglycerol Kinase inhibitor.

Safety

• Safety Statements: 23-24/25
• WGK Germany: 3