BritishPharmacopoeia(BP)ReferenceStandard , 87679-37-6

Synonym(s):
(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid;Mavik;Trandolapril

CAS NO.：87679-37-6

Empirical Formula: C24H34N2O5

Molecular Weight: 430.54

MDL number: MFCD00865776

EINECS: 618-046-0

PRODUCT Properties

• Melting point: 122-123°C
• Boiling point: 626.0±55.0 °C(Predicted)
• Density: 1.181±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: ≥20mg/mL
• form: white powder
• pka: 3.15±0.20(Predicted)
• color: White to Off-White
• InChIKey: VXFJYXUZANRPDJ-WTNASJBWSA-N
• SMILES: N1(C(=O)[C@@H](N[C@H](C(OCC)=O)CCC2=CC=CC=C2)C)[C@]2([H])[C@]([H])(CCCC2)C[C@H]1C(O)=O
• CAS DataBase Reference: 87679-37-6(CAS DataBase Reference)

Description and Uses

Trandolapril is a new ACE inhibitor that is rapidly hydrolyzed, mainly in the liver, to its biologically active form, trandolaprilat. Compared with all other ACE inhibitors, trandolaprilat is reported to have the highest lipophilicity and the most prolonged ACE inhibitory activity. In hypertensive patients, trandolapril at a dose of 2 mg reduces blood pressure consistently throughout the 24 hour period after intake, making it one of the best once a day antihypertensive drugs. It has also been demonstrated to inhibit aortic atherosclerosis in the hyperlipidemic rabbit.

antibacterial

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H360D
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501
• WGK Germany: 3
• RTECS: NL6015178
• HS Code: 2933995300
• Hazardous Substances Data: 87679-37-6(Hazardous Substances Data)