PRODUCT Properties
| Melting point: | -57 °C |
| Boiling point: | 20 °C10 mm Hg(lit.) |
| Density | 1.64 |
| refractive index | n |
| Flash point: | >110°C |
| storage temp. | 2-8°C |
| solubility | Chloroform (Soluble), Ethyl Acetate (Sparingly) |
| form | Liquid |
| color | Clear colorless |
| Water Solubility | may decompose |
| Sensitive | Moisture Sensitive |
| Merck | 14,3334 |
| BRN | 970225 |
| Stability: | Hygroscopic, Moisture Sensitive |
| CAS DataBase Reference | 503-38-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Trichloromethyl chloroformate(503-38-8) |
| EPA Substance Registry System | Carbonochloridic acid, trichloromethyl ester (503-38-8) |
Description and Uses
Diphosgene (DP), trichloromethyl chloroformate, is a clear, colorless liquid with an odor similar to phosgene. It is noncombustible, a strong irritant to the eyes and tissues, and is toxic by inhalation and ingestion. DP has a boiling point of 127°C–128°C (263°F) and a vapor pressure of 4.2 at 68°F (20°C). The liquid density is 1.65, which is heavier than water, and a melting/freezing point of 314°F (157°C). Inhalation LC50 is 3600 mg/m3 for 10 min. Effects of exposure are quite similar to phosgene gas. Its molecular formula is ClCOOCCl3, and the structure and molecular formula are shown in Figure 8.38. The DOT lists diphosgene as a 6.1 poison liquid. The NFPA 704 designation for CG is estimated to be health 4, flammability 0, reactivity 1, and special 0. It has a four-digit UN identification number of 2972.
Reactant for preparation of:
- Cyclic carbamimidates using a monophosphine gold(i) catalyst
- N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands
- Prostate-specific membrane antigen-targeted anticancer prodrugs
- Potential west nile virus protease inhibitors
- Antibody-drug conjugates (ADCs)
- Erythromycin A derivatives
Safety
| Symbol(GHS) |   GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H302-H314-H330 |
| Precautionary statements | P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | T+,Xi |
| Risk Statements | 26/28-34-26/27/28-36/37/38 |
| Safety Statements | 26-28-36/37/39-45-28A-36 |
| RIDADR | UN 3277 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | LQ7350000 |
| F | 8-10-19 |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29159000 |
| Hazardous Substances Data | 503-38-8(Hazardous Substances Data) |
| Toxicity | LC100 in rabbits (10-20 minutes exposure to vapor): 0.9 mg/l air (Klika, Mysliveckova) |
