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S1618449

spray-driedforanalysisEMSURE ACS,Reag.PhEur , 10034-96-5

Synonym(s):
6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;6-Chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide;HCTZ;Hydrochlorothiazide

CAS NO.:10034-96-5

Empirical Formula: C7H8ClN3O4S2

Molecular Weight: 297.74

MDL number: MFCD00051765

EINECS: 200-403-3

Pack Size Price Stock Quantity
250g RMB573.12 In Stock
25kg RMB22871.93 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 273 °C
Boiling point: 577.0±60.0 °C(Predicted)
Density  1.6761 (rough estimate)
refractive index  1.6100 (estimate)
Flash point: 9℃
storage temp.  2-8°C
solubility  Very slightly soluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides
pka 7.9, 9.2(at 25℃)
form  solid
color  White to Off-White
Odor wh. or pract. wh. cryst. powd., odorless
Water Solubility  722mg/L(25 ºC)
λmax 318nm(H2O)(lit.)
Merck  14,4781
BRN  625101
BCS Class 3,4
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey JZUFKLXOESDKRF-UHFFFAOYSA-N
LogP -0.070

Description and Uses

Hydrochlorothiazide is one of the most widely used drugs of this series, and it is used for the same indications, as is chlorothiazide. Hydrochlorothiazide causes less inhibition of carbonic anhydrase, but causes 5–10 times more diuresis of sodium ions than chlorothiazide using the same dose.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xi,T,F,Xn
Risk Statements  22-42/43-36/38-23/25-36/37/38-39/23/24/25-23/24/25-11
Safety Statements  22-24-36/37-45-33-16-7-36/37/39-27-26
RIDADR  UN 1230 3/PG 2
WGK Germany  2
RTECS  DK9100000
Hazard Note  Irritant
TSCA  Yes
HS Code  29350090
Toxicity LD50 in mice (mg/kg): 590 i.v.; >8000 orally (Piala)

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