≥98%(HPLC),solid , 76081-98-6

Synonym(s):
2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile

CAS NO.：76081-98-6

Empirical Formula: C17H15N3O

Molecular Weight: 277.32

MDL number: MFCD00834620

PRODUCT Properties

• Density: 1.16±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: DMSO: >10 mg/mL, soluble
• form: solid
• pka: 5.85±0.10(Predicted)
• color: white to light tan

Description and Uses

SCH 28080 is a reversible K⁺-competitive inhibitor of H⁺/K⁺-ATPases that is best known for its ability to block acid secretion through its action against the gastric H⁺/K⁺-ATPase (IC₅₀ = 1.3 μM). It is effective against gastric H⁺/K⁺-ATPases from a variety of species and can inhibit colonic H⁺/K⁺-ATPases, but this activity appears to be species-dependent. SCH 28080 is also used to investigate the role of H⁺/K⁺-ATPases in non-mammalian organisms and to distinguish the actions of H⁺/K⁺-ATPases from other ATP-dependent transporters.

SCH 28080 is a potent inhibitor of H+,K+-ATPase.

Safety

• Safety Statements: 22-24/25
• WGK Germany: 3