98% , 76712-82-8
Synonym(s):
Histrelin
CAS NO.：76712-82-8
Empirical Formula: C66H86N18O12
Molecular Weight: 1323.53
MDL number: MFCD00133494
| Pack Size | Price | Stock | Quantity |
| 100mg | RMB7869.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| alpha | D20 -33.9° (c = 1 in acetic acid) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | powder |
| pka | 9.82±0.15(Predicted) |
| Stability: | Hygroscopic |
Description and Uses
Histrelin, a synthetic gonadotrophin-releasing hormone (GnRH) agonist, was introduced as a first-line therapy for the treatment of central precocious puberty. When administered over a prolonged period, it suppresses the release of gonadotrophin, inhibits ovarian and testicular steroidogenesis, and prevents sexual maturation. Superior to the traditional therapy with progestational agents, histrelin appears to have decelerating effects on skeletal maturation allowing more statural growth and significantly increased final adult height. Histrelin has also been used to treat other disorders including endometriosis, polycystic ovarian disease, uterine leiomyomas, severe premenstrual syndrome and to prevent acute intermittent porphyria.
[des-Gly10, D-His(Bzl)6]-LH-RH ethylamide has been used:
- for inducing Batrachoseps gravid females to oviposit
- for comparing the effect of LHRH (luteinizing hormone-releasing hormone) agonists and dopamine antagonists in Lithobates pipiens
- for inducing oviposition in females of Taricha granulosa and Ensatina eschscoltzii
- to induce spawning in Spea hammondii adults
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Danger |
| Hazard statements | H360 |
| Precautionary statements | P201-P308+P313 |
| Hazard Codes | T |
| Risk Statements | 60 |
| Safety Statements | 53-22-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | OK6370800 |
| HS Code | 3504009000 |
