99% , 139755-83-2

CAS NO.：139755-83-2

Empirical Formula: C22H30N6O4S

Molecular Weight: 474.58

MDL number: MFCD00867528

EINECS: 604-158-7

PRODUCT Properties

• Melting point: 187-189°C
• Density: 1.39±0.1 g/cm3(Predicted)
• Flash point: 9℃
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: pKa 8.7 (Uncertain)
• color: White to Off-White
• InChIKey: BNRNXUUZRGQAQC-UHFFFAOYSA-N
• CAS DataBase Reference: 139755-83-2(CAS DataBase Reference)
• EPA Substance Registry System: 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl- (139755-83-2)

Description and Uses

Sildenafil was launched as Viagra in the US for the treatment of organic orland psychological male erectile dysfunction (ED). It is an orally bioavailable pyrazolopyrimidinone derivative structurally related to zaprinast, with vasodilating and potential anti-inflammatory activities. Upon oral administration, sildenafil selectively targets and inhibits cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), thereby inhibiting the PDE5-mediated degradation of cGMP found in smooth muscle and increasing cGMP availability. This results in prolonged smooth muscle relaxation in the corpus cavernosum of the penis, thereby causing vasodilation, blood engorgement and a prolonged penile erection.

Sildenafil is a phosphodiesterase-5 (PDE5) inhibitor. It is indicated for the treatment of erectile dysfunction (ED). Sildenafil is an orally active selective type 5 cGMP phosphodiesterase inhibitor.

Safety

• Symbol(GHS): GHS02,GHS06,GHS08
• Signal word: Danger
• Hazard statements: H225-H301+H311+H331-H370
• Precautionary statements: P210-P260-P280-P301+P310-P311
• Hazard Codes: Xi,T,F
• Risk Statements: 36/37/38-39/23/24/25-23/24/25-11
• Safety Statements: 22-24/25-36-26-45-36/37-16-7
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 1
• HS Code: 38220090
• Hazardous Substances Data: 139755-83-2(Hazardous Substances Data)