M9262234
lavendustinA , BR , 125697-92-9
Synonym(s):
5-Amino-[(N-2,5-dihydroxybenzyl)-Nʹ-2-hydroxybenzyl]salicylic Acid, RG14355;Lavendustin A - CAS 125697-92-9 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB1008.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 205-215 °C |
| Boiling point: | 741.7±60.0 °C(Predicted) |
| Density | 1.495±0.06 g/cm3(Predicted) |
| RTECS | DG8578950 |
| storage temp. | −20°C |
| solubility | DMSO: soluble |
| pka | 2.31±0.10(Predicted) |
| form | crystalline |
| color | Yellow to brown |
| Sensitive | Air Sensitive |
| Stability: | Moisture Sensitive: Hygroscopic |
Description and Uses
Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 μM). It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis.
A potent tyrosine kinase inhibitor. Inhibition is competitive with ATP and is noncompetitive with the peptide.
