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M9262234

lavendustinA , BR , 125697-92-9

Synonym(s):
5-Amino-[(N-2,5-dihydroxybenzyl)-Nʹ-2-hydroxybenzyl]salicylic Acid, RG14355;Lavendustin A - CAS 125697-92-9 - Calbiochem

CAS NO.:125697-92-9

Empirical Formula: C21H19NO6

Molecular Weight: 381.38

MDL number: MFCD00153822

Pack Size Price Stock Quantity
1mg RMB1008.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 205-215 °C
Boiling point: 741.7±60.0 °C(Predicted)
Density  1.495±0.06 g/cm3(Predicted)
RTECS  DG8578950
storage temp.  −20°C
solubility  DMSO: soluble
pka 2.31±0.10(Predicted)
form  crystalline
color  Yellow to brown
Sensitive  Air Sensitive
Stability: Moisture Sensitive: Hygroscopic
CAS DataBase Reference 125697-92-9(CAS DataBase Reference)

Description and Uses

Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 μM). It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis.

A potent tyrosine kinase inhibitor. Inhibition is competitive with ATP and is noncompetitive with the peptide.

Safety

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  37/39-26
WGK Germany  3
HS Code  29225000

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