Aztreonam , 98% , 78110-38-0

Synonym(s):
[2S-[2α,3β(Z)]]-2-[[[1-(2-Amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid;2-[[(Z)-[1-(2-Amino-4-thiazolyl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methyl-propanoic acid;Aztreonam

CAS NO.：78110-38-0

Empirical Formula: C13H17N5O8S2

Molecular Weight: 435.43

MDL number: MFCD00072145

EINECS: 278-839-9

PRODUCT Properties

• Melting point: 227°C
• Density: 1.83
• refractive index: 1.6460 (estimate)
• storage temp.: room temp
• solubility: DMSO (Slightly), Water (Slightly, Heated, Sonicated)
• form: solid
• pka: pKa -0.7(H2O t=RT Iunde?ned) (Uncertain);2.75(H3O t=RT Iunde?ned) (Uncertain);3.91(H4O t=RT Iunde?ned) (Uncertain)
• color: white to beige
• Water Solubility: Soluble in DMF/water (1:1) at 50 mg/ml
• Merck: 14,925
• InChIKey: WZPBZJONDBGPKJ-VEHQQRBSSA-N
• SMILES: C(O)(=O)C(O/N=C(/C1=CSC(N)=N1)\C(N[C@@H]1C(=O)N(S(O)(=O)=O)[C@H]1C)=O)(C)C
• CAS DataBase Reference: 78110-38-0(CAS DataBase Reference)

Description and Uses

Aztreonam is the first member of the monobactam class of antibiotics to be introduced into the world market. It possesses high β-lactamase stability and moderately good activity against gram negative aerobes such as E. coli, S. marcescens, -9 Proteus Providencia, Salmonella, g. influenzae, E. gonorrhea, and &. pneumonia. While somewhat less potent against Pseudomonas aeruginosa, it is nonetheless one of the better β-lactams against this species. It has poor activity against gram positive organisms.

Aztreonam is a synthetic β-lactam antibiotic of the monobactam class. It is effective against Gram-negative bacteria but inactive against Gram-positive bacteria. Its mechanism of action involves the inhibition of mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking. Aztreonam is resistant to hydrolysis by some β-lactamases, but is inactivated by extended-spectrum β-lactamases.

Safety

• Symbol(GHS): GHS08,GHS09
• Signal word: Danger
• Hazard statements: H400-H334
• Precautionary statements: P273-P391-P501-P261-P285-P304+P341-P342+P311-P501
• Hazard Codes: Xn
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 22-24/25-36-26
• WGK Germany: 2
• RTECS: UA2451400
• HS Code: 29419000
• Toxicity: TDLo ivn-rat: 1100 mg/kg (7-17D preg):TER NKRZAZ33(Suppl 1),203,85