5''-O-DMT-5-iodo-2''-deoxyuridine , 97% , 104375-88-4

CAS NO.：104375-88-4

Empirical Formula: C30H29IN2O7

Molecular Weight: 656.46

MDL number: MFCD01631069

EINECS: 2017-001-1

PRODUCT Properties

• Melting point: >128 °C (decomp)
• Density: 1.60±0.1 g/cm3(Predicted)
• pka: 7.94±0.10(Predicted)
• InChIKey: RLDUYGSOCGOJTP-SKDNVIITNA-N
• SMILES: C(OC[C@@H]1[C@@H](O)C[C@H](N2C=C(C(=O)NC2=O)I)O1)(C1C=CC=CC=1)(C1=CC=C(OC)C=C1)C1=CC=C(OC)C=C1 |&1:3,4,7,r|

Description and Uses

5'-O-(Dimethoxytrityl)-5-iodo-2'-deoxyuridine (2'-Deoxy-5'-O-DMT-5-iodouridine) is an intercalating agent that binds to DNA and RNA. It can be used as a probe for the detection of specific sequences in human cells. The fluorophore attached to the molecule allows it to be detected by fluorescence microscopy, while the chromophore is responsible for its ability to emit light at a wavelength of 535 nm. 2'-Deoxy-5'-O-DMT-5-iodouridine has been shown to enhance nucleotide excision repair and increase the sensitivity of cancer cells to chemotherapy drugs such as cisplatin. The molecule can also be used as a fluorescent protein marker in her-2 gene amplification and overexpression studies.

2’-Deoxy-5’-O-DMT-5-iodouridine is a modified oligonucleotides designed for use in genetic analysis and RNA detection.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338