Histrelin(acetate) , 98% , 220810-26-4
CAS NO.：220810-26-4
Empirical Formula: C66H86N18O12
Molecular Weight: 1323.52
MDL number: MFCD00918679
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB3680.00 | In Stock |
|
| 20mg | RMB6384.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.25 mg/ml; PBS (pH 7.2): 10 mg/ml |
| form | A crystalline solid |
| color | White to off-white |
Description and Uses
Histrelin is a synthetic gonadotropin-releasing hormone (GNRH) agonist that binds to the GNRH receptor (GNRHR; Ki = 0.2 nM in CHO cells expressing the human receptor). It stimulates release of oxytocin and vasopressin ex vivo from the isolated rat hypothalamo-neurohypophysial system at a concentration of 100 nM. In vivo, the initial dose of histrelin (100 μg) stimulates acute increases in luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone serum levels (50-, 2.5-, and 15-fold, respectively), while chronic treatment leads to 95% decreases in LH and FSH responses in rhesus monkeys. Formulations containing histrelin have been used in the treatment of advanced prostate cancer and central precocious puberty.
Safety
| Symbol(GHS) |   GHS08,GHS07 |
| Signal word | Danger |
| Hazard statements | H334-H332-H317 |
| Precautionary statements | P261-P285-P304+P341-P342+P311-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P271-P304+P340-P312 |
