Conessine , 98% , 546-06-5

Synonym(s):
(3β)-N,N-dimethyl-con-5-enin-3-amine;Conessin;Neriine;Roquessine;Wrightine

CAS NO.：546-06-5

Empirical Formula: C24H40N2

Molecular Weight: 356.59

MDL number: MFCD00016752

EINECS: 208-897-2

PRODUCT Properties

• Melting point: 126-127°C
• alpha: D20 +25.3° (c = 0.7 in abs alc)
• Boiling point: 479.38°C (rough estimate)
• Density: 0.9492 (rough estimate)
• refractive index: 1.5640 (estimate)
• storage temp.: Store at RT
• solubility: ethanol: ≥2mg/mL
• form: powder
• pka: 10.20±0.70(Predicted)
• color: white to tan
• optical activity: +25.320 (c 0.7, ethanol)
• LogP: 6.060 (est)

Description and Uses

Conessine is a naturally occurring steroid alkaloid found in a number of plant species from the Apocynaceae family, which have been used in traditional herbal medicine as a treatment for amoebic dysentery. In a radioligand-based high-throughput screen, conessine demonstrated high affinity for both rat and human histamine H3 receptors (K_is = 5.2 and 24.5 nM, respectively) and high selectivity against histamine receptors H1, H2, and H4. Though conessine potently blocks H3 agonist-stimulated GTPγS binding in cell- and tissue-based functional assays and efficiently crosses the blood-brain barrier, it has a poor rate of CNS clearance.

antiamebic, antibacterial, antineoplastic, anesthetic (local)

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• RTECS: GK7621000
• HS Code: 2939799090