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M8194247

STO-609(acetate) , 98% , 1173022-21-3

CAS NO.:1173022-21-3

Empirical Formula: C21H14N2O5

Molecular Weight: 374.35

MDL number:

EINECS: 604-604-1

Pack Size Price Stock Quantity
10mg RMB2246.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >300 °C
storage temp.  2-8°C
solubility  Soluble in DMSO (up to 10 mg/ml).
form  Yellow solid.
color  Yellow
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Description and Uses

STO-609 (1173022-21-3) is a selective inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki = 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively).1 Binds to the? ATP-binding site.2 Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. Important tool for probing distinct CaMK pathways in LTP.3 Reduces starvation-induced autophagosomal membrane formation.4 Reverses age-associated decline in bone mass.5 Stimulates osteoblast formation, inhibits osteoclast differentiation.6

STO-609 is a cell-permeable inhibitor of calcium/calmodulin-dependent kinase kinases (CaMKK) isoforms CaMKKα and CaMKKβ. It is used to evaluate the action of CaMKK isoforms both in vitro and in cells.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338