STO-609(acetate) , 98% , 1173022-21-3

CAS NO.：1173022-21-3

Empirical Formula: C21H14N2O5

Molecular Weight: 374.35

MDL number:

EINECS: 604-604-1

PRODUCT Properties

• Melting point: >300 °C
• storage temp.: 2-8°C
• solubility: Soluble in DMSO (up to 10 mg/ml).
• form: Yellow solid.
• color: Yellow
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Description and Uses

STO-609 (1173022-21-3) is a selective inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki = 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively).1 Binds to the? ATP-binding site.2 Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. Important tool for probing distinct CaMK pathways in LTP.3 Reduces starvation-induced autophagosomal membrane formation.4 Reverses age-associated decline in bone mass.5 Stimulates osteoblast formation, inhibits osteoclast differentiation.6

STO-609 is a cell-permeable inhibitor of calcium/calmodulin-dependent kinase kinases (CaMKK) isoforms CaMKKα and CaMKKβ. It is used to evaluate the action of CaMKK isoforms both in vitro and in cells.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P280-P305+P351+P338