STO-609(acetate) , 98% , 1173022-21-3
CAS NO.:1173022-21-3
Empirical Formula: C21H14N2O5
Molecular Weight: 374.35
MDL number:
EINECS: 604-604-1
Pack Size | Price | Stock | Quantity |
10mg | RMB2246.40 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | >300 °C |
storage temp. | 2-8°C |
solubility | Soluble in DMSO (up to 10 mg/ml). |
form | Yellow solid. |
color | Yellow |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Description and Uses
STO-609 (1173022-21-3) is a selective inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki = 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively).1 Binds to the? ATP-binding site.2 Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. Important tool for probing distinct CaMK pathways in LTP.3 Reduces starvation-induced autophagosomal membrane formation.4 Reverses age-associated decline in bone mass.5 Stimulates osteoblast formation, inhibits osteoclast differentiation.6
STO-609 is a cell-permeable inhibitor of calcium/calmodulin-dependent kinase kinases (CaMKK) isoforms CaMKKα and CaMKKβ. It is used to evaluate the action of CaMKK isoforms both in vitro and in cells.
Safety
Symbol(GHS) | ![]() GHS07 |
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P280-P305+P351+P338 |