Ac-YVAD-CHO(N-Ac-Tyr-Val-Ala-Asp-CHO) , 98% , 143313-51-3
Synonym(s):
Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem;IL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB849.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 937.7±65.0 °C(Predicted) |
| Density | 1.276±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMF:30.0(Max Conc. mg/mL);60.91(Max Conc. mM) DMSO:30.0(Max Conc. mg/mL);60.91(Max Conc. mM) Ethanol:30.0(Max Conc. mg/mL);60.91(Max Conc. mM) PBS (pH 7.2):5.0(Max Conc. mg/mL);10.15(Max Conc. mM) |
| form | Powder |
| pka | 4.20±0.10(Predicted) |
| color | White to off-white |
| Sensitive | Moisture Sensitive |
Description and Uses
Ac-YVAD-CHO is an inhibitor of caspase-1/interleukin-1β converting enzyme (ICE; Ki = 0.76 nM) and an acetylated form of the caspase-1 inhibitor YVAD-CHO . It is selective for caspase-1 over caspase-4, -5, -8, -9, and -10 (Kis = 163-970 nM), as well as over caspase-2, -3, -6, and -7 (Kis = >10,000 nM for all). It inhibits activation of caspase-1 and IL-1β in a cell-free assay using LPS-treated THP-1 cell homogenates when used at a concentration of 5 μM. Ac-YVAD-CHO (12.5 μmol/kg) reduces pancreatic levels of IL-18 and serum levels of IL-1β, as well as reduces pyroptosis of pancreatic cells, in a mouse model of cerulein-induced acute pancreatitis but does not decrease pancreatic expression of NOD-like receptor protein 3 (NLRP3). It increases susceptibility to lethal E. coli infection but prevents LPS-induced death in C3H/HeN mice when administered at doses of 5 and 10 mg/kg, respectively.
A potent, specific, and reversible inhibitor of caspases-1, -4 and -5
Safety
| WGK Germany | 3 |
