M8145847
ZaragozicAcidA , 98% , 142561-96-4
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB2999.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| alpha | D22 +18.3° (c = 0.60 in CHCl3); D25 +37° (c = 1.29 in methanol) |
| Boiling point: | 850.1±65.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Soluble in DMSO |
| form | solid |
| pka | 1.47±0.70(Predicted) |
| color | white to light tan |
| CAS DataBase Reference | 142561-96-4 |
Description and Uses
Zaragozic acid A is the major metabolite of a class of unusual bicyclic tricarboxylic acids, produced by a number of fungi in the genera Curvularia, Exserohilum, Setosphaeria and others, discovered at Merck and Glaxo in the early 1990s. In nature, zaragozic acid A acts as broad spectrum antifungal but its mode of action as an inhibitor of squalene synthase, involved in sterol biosynthesis, lead to investigation as a cholesterol lowering agent. Zaragozic acid A prepared by BioAustralis is presented as the free acid rather than the tri-sodium salt to avoid stability problems associated with hydrolysis of the salt.
Safety
| WGK Germany | 3 |
