M8144447
SEN-177 , 98% , 2117405-13-5
CAS NO.：2117405-13-5
Empirical Formula: C18H19FN6
Molecular Weight: 338.38
MDL number:
EINECS: 821-054-9
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB4000.80 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 581.3±60.0 °C(Predicted) |
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO:36.0(Max Conc. mg/mL);106.3(Max Conc. mM) |
| pka | 6.72±0.31(Predicted) |
| form | Solid |
| color | Brown to gray |
Description and Uses
SEN177 is an orally effect glutamine cyclase (QC) inhibitor. The Ki of SEN177 for human glutamine cyclase (hQC) is 20 nM, and the IC50 is 13 nM. SEN177 interferes with the interaction between CD47 and SIRRPα, and has anti-tumor activity. SEN177 reduces aggregation and apoptosis caused by HTT mutation in Huntington model, and can be used in the study of neurodegenerative diseases[1][2][3].
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P310-P330-P405-P501 |