(S,R,S)-AHPC-C6-PEG3-C4-Cl(VH032-C6-PEG3-C4-Cl) , 98% , 1835705-55-9
Synonym(s):
(S,R,S)-AHPC-6-2-2-6-Cl;(2S,4R)-1-((S)-2-(tert-Butyl)-22-chloro-4-oxo-10,13,16-trioxa-3-azadocosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;Crosslinker?E3 Ligase ligand conjugate;Protein degrader building block for PROTAC research;Template for synthesis of targeted protein degrader
CAS NO.：1835705-55-9
Empirical Formula: C38H59ClN4O7S
Molecular Weight: 751.42
MDL number: MFCD31560478
| Pack Size | Price | Stock | Quantity |
| 100mg | RMB4888.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 924.3±65.0 °C(Predicted) |
| Density | 1.174±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Ethanol: 100 mg/mL (133.08 mM); DMSO: ≥ 100 mg/mL (133.08 mM) |
| form | Oil |
| pka | 14.08±0.40(Predicted) |
| color | Light yellow to yellow |
Description and Uses
Protein degrader builiding block (S,R,S)-AHPC-C6-PEG3-butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |