Norfluoxetinehydrochloride(Desmethylfluoxetine) , 98% , 57226-68-3
CAS NO.：57226-68-3
Empirical Formula: C16H17ClF3NO
Molecular Weight: 331.76
MDL number: MFCD01321043
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB848.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | -20°C |
| solubility | H2O: >4 mg/mL |
| form | solid |
| color | yellow |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Description and Uses
Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent.
Norfluoxetine hydrochloride has been used to examine if psychoactive pharmaceuticals in drinking water at environmental concentrations could induce neuronal gene expression. It has also been used to examine whether at environmental concentrations it can alter in vitro expression of autism spectrum disorders (ASD)-associated synaptic proteins in human neurons.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| WGK Germany | 3 |
