1-OctadecylLysophosphatidicAcid(1-OctadecylLPA) , 98% , 52977-29-4

CAS NO.：52977-29-4

Empirical Formula: C21H45O6P

Molecular Weight: 424.55

MDL number: MFCD11045839

PRODUCT Properties

• storage temp.: Store at -20°C
• solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; Ethanol:PBS (pH 7.2) ((1:1): 0.5 mg/ml
• form: A crystalline solid

Description and Uses

1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.^1,2 Alkyl ether-linked LPA derivatives have a higher platelet aggregating activity than the acyl derivatives, most likely stemming from an alkyl-specific LPA receptor. For example, 1-octadecyl LPA has a platelet aggregating EC₅₀ value of 9 nM versus 1-octadecanoyl LPA which has an EC₅₀ value of 177 nM.³