Tibolone , 98% , 5630-53-5

Synonym(s):
(7α,17α)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one;17-Hydroxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-3-one;5(10)-Estren-7α-methyl-17α- ethynyl-17β- ol-3-one

CAS NO.：5630-53-5

Empirical Formula: C21H28O2

Molecular Weight: 312.45

MDL number: MFCD00864178

EINECS: 227-069-1

PRODUCT Properties

• Melting point: 169 °C
• Boiling point: 447.4±45.0 °C(Predicted)
• Density: 1.13±0.1 g/cm3(Predicted)
• refractive index: 105 ° (C=0.54, CH2Cl2/Et2O)
• storage temp.: 2-8°C
• solubility: DMSO: soluble15mg/mL, clear
• pka: 13.10±0.60(Predicted)
• color: white to beige
• Merck: 9427
• InChI: InChI=1/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/s3
• InChIKey: WZDGZWOAQTVYBX-PGFZCDQENA-N
• SMILES: [C@@]12([H])[C@H](C)CC3CC(=O)CCC=3[C@@]1([H])CC[C@]1(C)[C@](CC[C@@]21[H])(O)C#C |&1:0,2,12,16,18,21,r|
• CAS DataBase Reference: 5630-53-5(CAS DataBase Reference)

Description and Uses

Tibolone is a synthetic steroid with weak progestational and estrogenic properties, reportedly useful in controlling symptoms resulting from natural or surgical menopause. It has thus far shown no significant antithrombotic effect in post-menopausal patients.

A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H319
• Precautionary statements: P264-P280-P305+P351+P338-P337+P313
• Hazard Codes: N
• Risk Statements: 51/53
• Safety Statements: 22-24/25-61
• RIDADR: UN 3077 9/PG 3
• RTECS: RC8964020