Sinefungin , 98% , 58944-73-3
Synonym(s):
sf;Foxp3;JM2;Mast Cell Growth Factor (MGF);scurfin
CAS NO.：58944-73-3
Empirical Formula: C15H23N7O5
Molecular Weight: 381.39
MDL number: MFCD00057013
EINECS: 637-385-5
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB1174.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| alpha | D25 -2.61° (c = 5 in water); D23 +12 ±2° (c = 0.227 in water) |
| Boiling point: | 783.2±70.0 °C(Predicted) |
| Density | 1.91±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble |
| form | powder |
| pka | pKa (66% DMF): 2.9, 3.9, 8.9, 10.2(at 25℃) |
| color | white to yellow |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month. |
Description and Uses
Sinefungin (58944-73-3) is a nucleoside S-adenosyl-1-methionine analog. Potent, competitive methyltransferase (protein, DNA, and RNA methyltransferases) inhibitor.1,2?IC50?< 1.0 and 2.5 μM for PRMT1 and SET7/9, respectively.3?Sinefungin binds with greater affinity to the adenine-specific DNA methyltransferase M.TaqI than S-adenosyl-L-homocysteine.4?Inhibits biofilm formation by?Streptococcus pneumoniae.5
Sinefungin is a natural nucleoside analog of S-adenosylmethionine and inhibits Streptococcus pneumoniae biofilm growth. Its derivatives can be used as inhibitors and structure probes for human protein lysine methyltransferase SETD2.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| WGK Germany | 3 |
| RTECS | HE3140000 |
| HS Code | 29419090 |
| Toxicity | LD50 s.c. in mice: 185 mg/kg (Hamill, Hoehn, J. Antibiot.) |
