UBP302 , 98% , 745055-91-8
Synonym(s):
(αS)-α-amino-3-[(2-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB9328.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 207.9-208.5 °C (decomp)(Solv: water (7732-18-5)) |
| Boiling point: | 603.0±65.0 °C(Predicted) |
| Density | 1.525±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | DMSO: ≥5mg/mL at 60°C (with warming for 5 minutes) |
| pka | 2.12±0.10(Predicted) |
| form | powder |
| color | white to off-white |
Description and Uses
UBP 302 is an antagonist of glutamate receptor 5 (GluR5) subunit-containing kainate receptors that inhibits kainate-induced responses in isolated rat dorsal roots (Kd = 402 nM). In vitro, UBP 302 inhibits gamma frequency oscillations in the rat basolateral amygdala at a concentration of 25 μM, and blocks kainate receptor signaling in layer III neurons within the mouse medial entorhinal cortex at 20 μM, abrogating the intense synaptic activity characteristic of the Up state of cortical slow oscillation. In vivo, UBP 302 (250 mg/kg) significantly reduces seizure severity in a rat model of soman-induced status epilepticus.
UBP 302 is a potent and selective GLUK5 receptor antagonist.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |