2-ArachidonylGlycerolether , 98% , 222723-55-9
Synonym(s):
2-[(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraen-1-yloxy]-1,3-propanediol; 2-AG ether;2-Arachidonylglyceryl ether;HU 310
CAS NO.：222723-55-9
Empirical Formula: C23H40O3
Molecular Weight: 364.56
MDL number: MFCD05865095
EINECS: 200-578-6
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB2158.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 488.9±45.0 °C(Predicted) |
| Density | 0.948±0.06 g/cm3(Predicted) |
| Flash point: | 14℃ |
| storage temp. | Desiccate at -20°C |
| solubility | DMF: 20 mg/ml; DMSO: 15 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 500 μg/ml |
| pka | 13.92±0.10(Predicted) |
| form | ethanol solution (10 mg/mL (1% w/v)) |
| color | colorless to light yellow |
Description and Uses
2-Arachidonyl glycerol ether (2-AG ether) selectively binds to cannabinoid (CB) receptor 1 (Kis = 21.2 and >3,000 nM for CB1 and CB2, respectively, in a radioligand binding assay). It is a potent and selective agonist of CB1 and GPR55 with EC50 values of 10, 37, and >30,000 nM for CB1, GPR55, and CB2, respectively. 2-AG ether displays the typical tetrad of CB activities in mice. It is more chemically stable than 2-AG , with an endogenous half-life of hours rather than minutes. However, it is at least 10-fold less potent than 2-AG in eliciting typical CB1-mediated responses. 2-AG ether elicits modest reductions in intraocular pressure in rabbits when administered at doses exceeding 50 μg per eye. It increases aqueous humor outflow via the CB1 receptor in the trabecular meshwork. Administration of 2-AG ether to the nucleus accumbens (0.0625-1 μg) increases dietary intake and enhances fat consumption in rats given access to both high-carbohydrate and high-fat diets.
HU 310 is an endogenous GPR55 and CB1 receptors agonist. HU 310 has been shown to induce hyperglycia in rats. HU 310 can be used to investigate the biological roles of GPR55 and CB1 receptors.
Safety
| Symbol(GHS) |   GHS02,GHS07 |
| Signal word | Danger |
| Hazard statements | H225-H319 |
| Precautionary statements | P210-P305+P351+P338 |
| Hazard Codes | F |
| Risk Statements | 11 |
| Safety Statements | 7-16 |
| RIDADR | UN1170 - class 3 - PG 2 - Ethanol, solution |
| WGK Germany | 2 |
